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Pucadyil Lab

Membrane remodelling in cellular physiology

The ~5 nanometer-thin biological membrane is formed spontaneously by the the non-covalent assembly of amphipathic lipids. Membranes are fluid and capable of resealing quickly upon rupture thereby making them highly resilient materials. Perhaps, this feature explains why lipids were selected over the course of evolution to form membranes that encapsulate all living entities. Membranes are also elastic materials that resist remodelling. But biological membranes are constantly bent out of shape, cut and resealed through budding, fission and fusion reactions, which are collectively referred to as membrane remodelling. 

Membrane remodelling is managed by specialised protein machines. The Pucadyil Lab focuses on discovering membrane remodelling proteins and understanding their mechanistic and regulatory aspects. We carry out biochemical screens to identify such proteins, employ reconstitution approaches to understand how they work and investigate their functions in living systems.

Lab news

October 27-29 , 2024

August , 2024

  • Shivansh and Sejal join the Pucadyil Lab as graduate students. 

May 29, 2024

  • Swayam graduates with a BS-MS degree. Himani, Shomu and Krishnendu graduate with a Ph.D. Himani received the best thesis award in the Biology department. 
     

May 1, 2024

April 9, 2024

  • Soumya's paper on reconstituting membrane tubulation and fission using novel cushioned bilayer templates accepted in PNAS.
     

March 4, 2024

  • Krishnendu graduates with a Ph.D. !!!
     

February 13, 2024

  • Himani graduates with a Ph.D. !!!
     

February 5, 2024

  • Soumya graduates with a Ph.D. !!!

September 17, 2023

  • Soumya's paper on reconstituting membrane tubulation and fission using novel cushioned bilayer templates posted on the bioarxiv.
     

June 19, 2023

March 21, 2023

March 16, 2023

  • Thomas' invited perspective piece on mitochondrial fission published in Molecular Cell.
     

February 9, 2023

  • Himani's paper on a novel variable loop in dynamin accepted in PNAS.
     

February 4, 2023

January 20-24, 2023

  • The Pucadyil Lab attends the 45th All India Cell Biology Conference at Varanasi. This is somewhat of a lab retreat as well (see the photos).
     

September 4, 2022

  • Himani's paper on a novel variable loop in dynamin posted on the bioarxiv.
     

August 30, 2022

June 22, 2022

April 19, 2022

  • The Pucadyil Lab gets awarded the Team Science Grant from DBT Wellcome Trust India Alliance.
     

February 14, 2022

  • Devika's and Himani's paper on SUPER template pulldowns accepted in a special issue dedicated to Erwin London in the Journal of Membrane Biology.

  • Krishnendu's paper on metal binding in the mitochondrial Drp1 accepted in a special issue of membrane remodelling in the Journal of Membrane Biology.

Indian Institute of Science Education and Research

Dr. Homi Bhabha Road, Pashan, Pune 411008, Maharashtra, INDIA

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