Pucadyil lab

the biology of membrane fission

 

Cell membranes are spontaneously formed by the self-assembly of lipids into a 5-nm thin bilayer sheet. They have unique mechanical properties. Foremost among them is their ability to resist rupture. This property lies at the heart of evolution choosing lipids as the material to contain life within membrane-bound compartments. But cells have also evolved mechanisms to compartmentalize the cytoplasm into vesicles and organelles. Formation of  vesicles and the division of organelles requires active bending and fission of the membrane, which are processes that are managed by specialized protein machines. Our research focuses on identifying such protein machines and understanding where and how they function in cells.

Thomas Pucadyil

 

Indian Institute of Science Education and Research

Dr. Homi Bhabha Road, Pashan, Pune 411 008, Maharashtra INDIA

E-mail: pucadyil@iiserpune.ac.in

Phone: +91 20 2590 8204

Twitter: @TPucadyil

Curriculum vitae

Know more about Thomas here...

http://jcb.rupress.org/content/211/4/720